The church of San Domenico is one of the most famous sacred buildings of Arezzo due to its presence, inside the Wooden Crucifix painted by Cimabue , considered one of the masterpieces of 13th century painting , datable to the late sixties. In January 1276, in the place where it was still under construction, the church of San Domenico hosted what for the Church of Rome was the first conclave in history . In April 1960 Pope John XXIII raised it to the dignity of a minor basilica.

The church, in Gothic style, was started in 1275 and finished in the XIV century . The financial contributions of the Ubertini and Tarlati families contributed to its construction. The asymmetric masonry façade also includes a bell tower with two bells.

The interior with a trussed roof has only one nave, which takes light from 12 single-light windows (6 per side) whose mutual distance decreases as you approach the apse, thus giving a greater sense of depth to the classroom

The internal pictorial decoration, fourteenth century, is still well documented.

It is a mature work (1395-1400) by Spinello Aretino, the fresco with the Saints Filippo and Giacomo Minore and stories of their life and of Santa Caterina, on the internal wall of the façade. Of the son Parri di Spinello is the Crucifixion among saints, on the right side of the internal wall of the façade: on the right of the Crucifix are depicted the Virgin and St. Nicholas and on the left the saints John and Dominic.

The Dragomanni chapel , a family in which a dragon figured, has a Gothic structure with a black stone altar sculpted by Giovanni di Francesco from Florence (1368) and a fresco representing the adolescent Jesus who talks with the doctors of the Temple , by the Sienese Luca di Tommè.

In a niche a glazed terracotta by Giovanni and Girolamo della Robbia, built between 1515 and 1520, represents San Pietro da Verona .

In the left chapel the triptych of Giovanni d’Agnolo , on the altar, represents: in the center the Archangel Michael, on his right (left for those looking) San Domenico, and to his left San Paolo.

In the chapel on the right, where the Eucaristia is kept, a Madonna with Child in stone, anonymous work of the Arezzo area, once part of the series of sculptures that from 1339 decorated the ten doors of the walls of the city, here hospitalized to remove it from the deterioration caused by exposure to the elements.

In the church was buried the Renaissance painter Niccolò Soggi , mentioned by Vasari in his The lives of the most excellent painters, sculptors and architects.